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Sep 20, 2023 · The gut-brain connection is complex and bidirectional. Signals pass both ways between your digestive system and central nervous system, and health or disease in one can …

Here we describe the organization and functions of the ENS and then review the evidence for ENS involvement in two common neurodegenerative disorders, Parkinson’s disease (PD) and …

Jul 20, 2016 · The enteric nervous system is vital for life, and its dysfunction participates not only in digestive disorders, but also in diseases of the central nervous system (CNS).

The enteric nervous system is the largest and most complex unit of the peripheral nervous system, with ~600 million neurons releasing a multitude of neurotransmitters to facilitate the …

The enteric nervous system (ENS) is large, complex and uniquely able to orchestrate gastrointestinal behaviour independently of the central nervous system (CNS). An intact ENS …

In this review, we discuss the latest evidence on the role of the ENS in the pathogenesis of enteric neuropathies, disorders of gut–brain interaction, inflammatory bowel diseases, and colorectal …

Jul 1, 2013 · Developmental studies in model organisms and genetic studies of the most common congenital disease of the ENS, Hirschsprung disease, have provided a detailed understanding …

Dec 11, 2012 · Here, Heather Young and colleagues provide an overview of the progress made in the past five years in our understanding of ENS development and the potential involvement of …

Apr 25, 1996 · Disorders of the enteric nervous system may result in motor, secretory, and inflammatory and immunologic dysfunction of the gut.

Feb 18, 2024 · This second brain is called the enteric nervous system (ENS). The ENS is made up of two thin layers that contain more than 100 million nerve cells.

Genes involved in Hirschsprung disease (HSCR) or known to be important to enteric nervous system (ENS) development are listed, and their mutant phenotypes are described. In addition, …

Many diseases that affect the PNS also involve the ENS. Among these are infections such as Chagas' disease and herpes simplex and metabolic disorders such as diabetes mellitus, AIP …

Congenital and acquired derangements in the structure or function of the enteric nervous system are well recognized as causes of digestive tract disease. Examples include small intestinal …

Feb 23, 2025 · Recognizing the signs of an imbalanced enteric nervous system can help address these issues early on. Digestive Discomfort: Bloating, gas, and abdominal pain are typical …

Mar 6, 2012 · The importance of the ENS is emphasized by the life-threatening effects of certain ENS neuropathies, including Hirschsprung disease and Chagas disease. Other ENS …

5 days ago · For example, it uses 30 different neurotransmitters. It is not entirely controlled by the CNS but is connected to the CNS via a communication network called the brain-gut axis. The …

3 days ago · The enteric nervous system (ENS) is often referred to as the “second brain” due to its complex neural networks that regulate gut function independently of the central nervous …

The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract, is a vast, mesh-like network of neurons and glia embedded within the bowel wall. Through its …

Failure of enteric NC-derived cells (ENCDCs) to colonize the distal bowel causes Hirschsprung disease (HSCR), a common (1 in 5,000 live births) and life-threatening developmental …

5 days ago · The enteric nervous system, also known as the ‘second brain’, is embedded in the walls of the GI tract (esophagus to rectum). It contains approximately 500 million neurons …

1 day ago · Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Amyloid-β (Aβ) accumulation and neurofibrillary tangles are two key histological features …

2 days ago · Aberrant ILC responses have been implicated in the pathogenesis of chronic inflammatory diseases, ... there is increasing evidence that regulation by the enteric nervous …